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Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.
Leung, Eric; Cairns, Rob A; Chaudary, Naz; Vellanki, Ravi N; Kalliomaki, Tuula; Moriyama, Eduardo H; Mujcic, Hilda; Wilson, Brian C; Wouters, Bradly G; Hill, Richard; Milosevic, Michael.
Afiliación
  • Leung E; Department of Radiation Oncology, Sunnybrook Health Sciences Centre and Odette Cancer Centre, Toronto, Canada.
  • Cairns RA; Department of Radiation Oncology, University of Toronto, Toronto, Canada.
  • Chaudary N; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
  • Vellanki RN; Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • Kalliomaki T; Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • Moriyama EH; Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • Mujcic H; Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • Wilson BC; Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • Wouters BG; Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • Hill R; Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • Milosevic M; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
BMC Cancer ; 17(1): 418, 2017 Jun 15.
Article en En | MEDLINE | ID: mdl-28619042
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Consumo de Oxígeno / Ácido Láctico / Subunidad alfa del Factor 1 Inducible por Hipoxia / Hipoxia / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Canadá
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Consumo de Oxígeno / Ácido Láctico / Subunidad alfa del Factor 1 Inducible por Hipoxia / Hipoxia / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Canadá