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Novel chemical probes for the investigation of nonribosomal peptide assembly.
Ho, Y T Candace; Leng, Daniel J; Ghiringhelli, Francesca; Wilkening, Ina; Bushell, Dexter P; Kostner, Otto; Riva, Elena; Havemann, Judith; Passarella, Daniele; Tosin, Manuela.
Afiliación
  • Ho YTC; Department of Chemistry, University of Warwick, Library Road, CV4 7AL, UK. M.Tosin@warwick.ac.uk.
  • Leng DJ; Department of Chemistry, University of Warwick, Library Road, CV4 7AL, UK. M.Tosin@warwick.ac.uk.
  • Ghiringhelli F; Department of Chemistry, University of Warwick, Library Road, CV4 7AL, UK. M.Tosin@warwick.ac.uk and Department of Chemistry, Universita' degli Studi di Milano, Via Golgi, 19 20133 Milano, Italy.
  • Wilkening I; Department of Chemistry, University of Warwick, Library Road, CV4 7AL, UK. M.Tosin@warwick.ac.uk.
  • Bushell DP; Department of Chemistry, University of Warwick, Library Road, CV4 7AL, UK. M.Tosin@warwick.ac.uk.
  • Kostner O; Department of Chemistry, University of Warwick, Library Road, CV4 7AL, UK. M.Tosin@warwick.ac.uk and Institut für Organische Chemie, Universität Wien, Währinger Str., 38 1090 Wien, Austria.
  • Riva E; Department of Chemistry, University of Warwick, Library Road, CV4 7AL, UK. M.Tosin@warwick.ac.uk.
  • Havemann J; Department of Chemistry, University of Warwick, Library Road, CV4 7AL, UK. M.Tosin@warwick.ac.uk.
  • Passarella D; Department of Chemistry, Universita' degli Studi di Milano, Via Golgi, 19 20133 Milano, Italy.
  • Tosin M; Department of Chemistry, University of Warwick, Library Road, CV4 7AL, UK. M.Tosin@warwick.ac.uk.
Chem Commun (Camb) ; 53(52): 7088-7091, 2017 06 27.
Article en En | MEDLINE | ID: mdl-28627528
Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sondas Moleculares / Equinomicina Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sondas Moleculares / Equinomicina Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article