Your browser doesn't support javascript.
loading
Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos.
Zhang, Jingye; Tao, Wenrong; Liu, Hui; Yu, Guanling; Li, Mei; Ma, Shuiying; Wu, Keliang.
Afiliación
  • Zhang J; Center for Reproductive Medicine, Shandong University, 157 Jingliu Road, Jinan, 250021, China.
  • Tao W; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.
  • Liu H; The Key laboratory for Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, China.
  • Yu G; Center for Reproductive Medicine, Shandong University, 157 Jingliu Road, Jinan, 250021, China.
  • Li M; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.
  • Ma S; The Key laboratory for Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, China.
  • Wu K; Center for Reproductive Medicine, Shandong University, 157 Jingliu Road, Jinan, 250021, China.
J Assist Reprod Genet ; 34(9): 1173-1178, 2017 Sep.
Article en En | MEDLINE | ID: mdl-28676910
PURPOSE: This study aimed to test whether there is an association between embryo morphokinetic parameters and ploidy status. METHODS: Patients with high risk of aneuploidy were analyzed by time-lapse microscopy combined with preimplantation genetic screening (PGS). Accordingly, 256 blastocysts from 75 patients were subjected to trophectoderm biopsy and microarray comparative genomic hybridization (array-CGH). Blastocyst development process was analyzed using time-lapse images. RESULTS: Morphokinetic parameters: tPNf, t2, t3, t4, t5, t8, t9, tcom, tM, tSB, tB, tEB, CC1, CC2, CC3, S2, S3, t5-t2, and tB-tSB showed no significant difference in euploid embryos compared to aneuploid counterparts. In addition, two risk models based on previously published morphokinetic parameters failed to segregate euploid from aneuploid embryos. CONCLUSIONS: Morphokinetic parameters subjected to investigation in the present study failed to improve the chance of selecting euploid embryos.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fertilización In Vitro / Desarrollo Embrionario / Imagen de Lapso de Tiempo / Aneuploidia Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: J Assist Reprod Genet Asunto de la revista: GENETICA / MEDICINA REPRODUTIVA Año: 2017 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fertilización In Vitro / Desarrollo Embrionario / Imagen de Lapso de Tiempo / Aneuploidia Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: J Assist Reprod Genet Asunto de la revista: GENETICA / MEDICINA REPRODUTIVA Año: 2017 Tipo del documento: Article País de afiliación: China
...