Total Synthesis of Bruceolline I.
J Nat Prod
; 80(8): 2384-2388, 2017 08 25.
Article
en En
| MEDLINE
| ID: mdl-28731697
ABSTRACT
The first total synthesis of the natural product bruceolline I, isolated in small quantities from the ethanol extract of Brucea mollis stems, was achieved in 29% yield over nine steps and with high enantiomeric purity (>98%). The key step of the process is the tandem gold-catalyzed rearrangement/Nazarov reaction of a propargylic acetate derivative. This synthesis provides a sufficient amount of synthesized bruceolline I for further bioassays.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tallos de la Planta
/
Ciclopentanos
/
Brucea
/
Indoles
Idioma:
En
Revista:
J Nat Prod
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia