Compromised Telomeric Heterochromatin Promotes ALTernative Lengthening of Telomeres.
Trends Cancer
; 2(3): 114-116, 2016 03.
Article
en En
| MEDLINE
| ID: mdl-28741530
ABSTRACT
Alternative lengthening of telomeres (ALT) is an enigmatic process that allows certain cancers to maintain telomeres in the absence of telomerase. ALT cancers are frequently defective for ATRX/DAXX, a chaperone complex that deposits histone variant H3.3 at telomeres. We propose that mutations in alpha thalassemia-mental retardation syndrome X-linked (ATRX)/death-domain associated protein (DAXX) prime ALT activation by disrupting telomeric heterochromatin.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
/
Heterocromatina
/
Proteínas Adaptadoras Transductoras de Señales
/
Homeostasis del Telómero
/
Proteína Nuclear Ligada al Cromosoma X
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Trends Cancer
Año:
2016
Tipo del documento:
Article
País de afiliación:
Australia