Clinical utility of visualisation of nigrosome-1 in patients with Parkinson's disease.
Eur Radiol
; 28(2): 718-726, 2018 Feb.
Article
en En
| MEDLINE
| ID: mdl-28779393
ABSTRACT
OBJECTIVE:
To determine the diagnostic characteristics of poor visualisation of nigrosome-1 as a neuroimaging biomarker in Parkinson's disease (PD) and to explore the relationship of poor visualisation of nigrosome-1 and clinical asymmetry.METHODS:
High-resolution gradient-echo sequences of 67 patients with PD and 63 healthy controls were reviewed by two radiologists blinded to the clinical details. A three-tier classification system was used to categorise the scans based on the visualisation of nigrosome-1, and inter-rater reliability was calculated at each level of classification. Other diagnostic properties such as sensitivity, specificity and predictive values were calculated. The relationship between poor visualisation of nigrosome-1 and clinical asymmetry was also assessed.RESULTS:
Poor visualisation of nigrosome-1 had high sensitivity (98.5%), specificity (93.6%), positive-predictive value (94.3%), negative-predictive value (98.3%), accuracy (96%) and inter-rater reliability (k = 0.75-0.92). Poorly visualised nigrosome-1 was significantly associated with higher motor asymmetry in the contralateral side in 64.8% of subjects (p = 0.004).CONCLUSIONS:
Poor visualisation of nigrosome-1 in PD had good diagnostic properties as a neuroimaging biomarker in PD. There was also a significant agreement on clinical asymmetry and poor visualisation of nigrosome-1. KEY POINTS ⢠Nigrosome-1 represents the largest collection of dopaminergic neurons in dorso-lateral substantia nigra. ⢠Loss of nigrosome-1 is being studied as a biomarker in Parkinson's disease. ⢠Visualisation of nigrosome-1 had good diagnostic properties as a biomarker. ⢠There was a contralateral relationship between nigrosome-1 lateralisation and clinical asymmetry. ⢠We also highlight the potential limitations of nigrosome-1 visualisation as a biomarker.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Sustancia Negra
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Imagen por Resonancia Magnética
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Neuroimagen
Tipo de estudio:
Prognostic_studies
Aspecto:
Patient_preference
Límite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Eur Radiol
Asunto de la revista:
RADIOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
India