Impact of dose volume parameters and clinical factors on acute radiation oral mucositis for locally advanced nasopharyngeal carcinoma patients treated with concurrent intensity-modulated radiation therapy and chemoradiotherapy.
Oral Oncol
; 72: 32-37, 2017 09.
Article
en En
| MEDLINE
| ID: mdl-28797459
ABSTRACT
PURPOSE:
To prospectively identify the predictive value of different dosimetric parameters and also assess the predictors of acute radiation oral mucositis (ROM).METHODS:
In accordance with the RTOG scoring criteria, ninety-two patients with locally advanced nasopharyngeal carcinoma (NPC) treated with concurrent chemoradiotherapy were evaluated for acute ROM which was defined as severe when the score ≥3. Patients' medical records and dosimetric data exported from IMRT plan enable the authors to perform a statistical analysis for the parameters as potential predictors of severe ROM.RESULTS:
Body weight loss and V30Gy (p=0.017 and 0.003, respectively) are related factors to severe ROM. As the receiver operating characteristics (ROC) curve shows, the threshold value of V30 for severe ROM was 73.155% (sensitivity, 0.842; specificity, 0.671), and the area under V30Gy curves was 0.753 (p=0.001).CONCLUSION:
New parameters were found as predictors of severe ROM using dosimetric analysis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dosificación Radioterapéutica
/
Estomatitis
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Neoplasias Nasofaríngeas
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Radioterapia de Intensidad Modulada
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Quimioradioterapia
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Oral Oncol
Asunto de la revista:
NEOPLASIAS
Año:
2017
Tipo del documento:
Article
País de afiliación:
China