Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell apoptosis.

Fu, Xiafei; He, Yuanli; Wang, Xuefeng; Peng, Dongxian; Chen, Xiaoying; Li, Xinran; Wang, Qing

Fu, Xiafei; He, Yuanli; Wang, Xuefeng; Peng, Dongxian; Chen, Xiaoying; Li, Xinran; Wang, Qing.

Afiliación

Fu X; Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China. fxf1997@163.com.
He Y; Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Wang X; Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Peng D; Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Chen X; Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Li X; Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Wang Q; Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.

Stem Cell Res Ther ; 8(1): 187, 2017 08 14.

Article en En | MEDLINE | ID: mdl-28807003

Asunto(s)

Antineoplásicos/efectos adversos; Proteínas Reguladoras de la Apoptosis/metabolismo; Apoptosis; Células de la Granulosa/metabolismo; Ovario/patología; Fosfohidrolasa PTEN/metabolismo; Células Madre/metabolismo; Animales; Células Cultivadas; Femenino; Vectores Genéticos/metabolismo; Hormonas Esteroides Gonadales/metabolismo; Células de la Granulosa/patología; Lentivirus/metabolismo; Células Madre Mesenquimatosas/metabolismo; MicroARNs/genética; MicroARNs/metabolismo; Tamaño de los Órganos; ARN Mensajero/genética; ARN Mensajero/metabolismo; Ratas Wistar; Transfección

Palabras clave

Apoptosis; Bone marrow derived mesenchymal stem cells; Chemotherapy-induced premature ovarian failure; PDCD4; PTEN; miR-21

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ovario / Células Madre / Apoptosis / Fosfohidrolasa PTEN / Proteínas Reguladoras de la Apoptosis / Células de la Granulosa / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Stem Cell Res Ther Año: 2017 Tipo del documento: Article

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google