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Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.
Brockway, Anthony J; Volkov, Oleg A; Cosner, Casey C; MacMillan, Karen S; Wring, Stephen A; Richardson, Thomas E; Peel, Michael; Phillips, Margaret A; De Brabander, Jef K.
Afiliación
  • Brockway AJ; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038, USA.
  • Volkov OA; Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Rd., Dallas, TX 75390-9041, USA.
  • Cosner CC; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038, USA.
  • MacMillan KS; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038, USA.
  • Wring SA; Scynexis, Inc. (now Avista Pharma Solutions), 3501 Tricenter Blvd, Suite C, Durham, NC 27713, USA.
  • Richardson TE; Scynexis, Inc. (now Avista Pharma Solutions), 3501 Tricenter Blvd, Suite C, Durham, NC 27713, USA.
  • Peel M; Scynexis, Inc. (now Avista Pharma Solutions), 3501 Tricenter Blvd, Suite C, Durham, NC 27713, USA.
  • Phillips MA; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Rd., Dallas, TX 75390-9041, USA. Electronic address: Margaret.Phillips@UTSout
  • De Brabander JK; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038, USA. Electronic address: Jef.DeBrabander@UTSouthwestern.edu.
Bioorg Med Chem ; 25(20): 5433-5440, 2017 10 15.
Article en En | MEDLINE | ID: mdl-28807574
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenosilmetionina Descarboxilasa / Tripanocidas / Trypanosoma brucei brucei / Tripanosomiasis Africana / Desoxiadenosinas / Inhibidores Enzimáticos Límite: Animals Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenosilmetionina Descarboxilasa / Tripanocidas / Trypanosoma brucei brucei / Tripanosomiasis Africana / Desoxiadenosinas / Inhibidores Enzimáticos Límite: Animals Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos