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Conserved DNA methylation combined with differential frontal cortex and cerebellar expression distinguishes C9orf72-associated and sporadic ALS, and implicates SERPINA1 in disease.
Ebbert, Mark T W; Ross, Christian A; Pregent, Luc J; Lank, Rebecca J; Zhang, Cheng; Katzman, Rebecca B; Jansen-West, Karen; Song, Yuping; da Rocha, Edroaldo Lummertz; Palmucci, Carla; Desaro, Pamela; Robertson, Amelia E; Caputo, Ana M; Dickson, Dennis W; Boylan, Kevin B; Rademakers, Rosa; Ordog, Tamas; Li, Hu; Belzil, Veronique V.
Afiliación
  • Ebbert MTW; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Ross CA; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
  • Pregent LJ; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Lank RJ; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Zhang C; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
  • Katzman RB; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Jansen-West K; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Song Y; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • da Rocha EL; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
  • Palmucci C; Stem Cell Transplantation Program, Department of Pediatric Hematology and Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA, USA.
  • Desaro P; Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Robertson AE; Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Caputo AM; Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Dickson DW; Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Boylan KB; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Rademakers R; Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Ordog T; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Li H; Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
  • Belzil VV; Department of Physiology and Medical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Acta Neuropathol ; 134(5): 715-728, 2017 11.
Article en En | MEDLINE | ID: mdl-28808785
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cerebelo / Alfa 1-Antitripsina / Metilación de ADN / Proteína C9orf72 / Lóbulo Frontal / Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Acta Neuropathol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cerebelo / Alfa 1-Antitripsina / Metilación de ADN / Proteína C9orf72 / Lóbulo Frontal / Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Acta Neuropathol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos