Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity.

McGee-Lawrence, Meghan E; Pierce, Jessica L; Yu, Kanglun; Culpepper, Natasha R; Bradley, Elizabeth W; Westendorf, Jennifer J

McGee-Lawrence, Meghan E; Pierce, Jessica L; Yu, Kanglun; Culpepper, Natasha R; Bradley, Elizabeth W; Westendorf, Jennifer J.

Afiliación

McGee-Lawrence ME; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia.
Pierce JL; Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, Augusta, Georgia.
Yu K; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia.
Culpepper NR; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia.
Bradley EW; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia.
Westendorf JJ; Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.

J Cell Physiol ; 233(4): 2671-2680, 2018 04.

Article en En | MEDLINE | ID: mdl-28840938

Asunto(s)

Huesos/metabolismo; Histona Desacetilasas/deficiencia; Resistencia a la Insulina; Osteoprotegerina/metabolismo; Células Madre/metabolismo; Alelos; Animales; Biomarcadores/sangre; Dieta Alta en Grasa; Eliminación de Gen; Histona Desacetilasas/metabolismo; Ratones Endogámicos C57BL; Ratones Noqueados; Osteoblastos/metabolismo; Osteoprotegerina/sangre; Osteoprotegerina/genética; ARN Mensajero/genética; ARN Mensajero/metabolismo; Aumento de Peso

Palabras clave

energy metabolism; histone deacetylase 3; insulin sensitivity; mellitus; osteoblast; osteoprotegerin; type 2 diabetes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_cobertura_universal Asunto principal: Células Madre / Huesos / Resistencia a la Insulina / Osteoprotegerina / Histona Desacetilasas Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: J Cell Physiol Año: 2018 Tipo del documento: Article País de afiliación: Georgia

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