Genome maintenance functions of the INO80 chromatin remodeller.
Philos Trans R Soc Lond B Biol Sci
; 372(1731)2017 Oct 05.
Article
en En
| MEDLINE
| ID: mdl-28847826
ABSTRACT
Chromatin modification is conserved in all eukaryotes and is required to facilitate and regulate DNA-templated processes. For example, chromatin manipulation, such as histone post-translational modification and nucleosome positioning, play critical roles in genome stability pathways. The INO80 chromatin-remodelling complex, which regulates the abundance and positioning of nucleosomes, is particularly important for proper execution of inducible responses to DNA damage. This review discusses the participation and activity of the INO80 complex in DNA repair and cell cycle checkpoint pathways, with emphasis on the Saccharomyces cerevisiae model system. Furthermore, the role of ATM/ATR kinases, central regulators of DNA damage signalling, in the regulation of INO80 function will be reviewed. In addition, emerging themes of chromatin remodelling in mitotic stability pathways and chromosome segregation will be introduced. These studies are critical to understanding the dynamic chromatin landscape that is rapidly and reversibly modified to maintain the integrity of the genome.This article is part of the themed issue 'Chromatin modifiers and remodellers in DNA repair and signalling'.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN Helicasas
/
Reparación del ADN
/
Puntos de Control del Ciclo Celular
/
Proteínas de la Ataxia Telangiectasia Mutada
Idioma:
En
Revista:
Philos Trans R Soc Lond B Biol Sci
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos