Rebound syndrome after teriflunomide cessation in a patient with multiple sclerosis.

Yamout, Bassem I; Said, Marianne; Hannoun, Salem; Zeineddine, Maya; Massouh, Joelle; Khoury, Samia J

Yamout, Bassem I; Said, Marianne; Hannoun, Salem; Zeineddine, Maya; Massouh, Joelle; Khoury, Samia J.

Afiliación

Yamout BI; Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address: yamoutba@gmail.com.
Said M; Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon.
Hannoun S; Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon.
Zeineddine M; Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon.
Massouh J; Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon.
Khoury SJ; Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon.

J Neurol Sci ; 380: 79-81, 2017 Sep 15.

Article en En | MEDLINE | ID: mdl-28870594

ABSTRACT

ABSTRACT

We report a case of relapsing remitting multiple sclerosis (RRMS) with severe rebound syndrome 12weeks following discontinuation of teriflunomide therapy. The patient developed severe clinical relapses with significant increase in the number of brain and spine magnetic resonance imaging (MRI) lesions. She responded well to intravenous and oral steroids and was later maintained on rituximab.

Asunto(s)

Crotonatos/uso terapéutico; Factores Inmunológicos/uso terapéutico; Esclerosis Múltiple Recurrente-Remitente/tratamiento farmacológico; Síndrome de Abstinencia a Sustancias; Toluidinas/uso terapéutico; Adulto; Encéfalo/diagnóstico por imagen; Encéfalo/efectos de los fármacos; Médula Cervical/diagnóstico por imagen; Médula Cervical/efectos de los fármacos; Crotonatos/efectos adversos; Femenino; Humanos; Hidroxibutiratos; Factores Inmunológicos/efectos adversos; Esclerosis Múltiple Recurrente-Remitente/diagnóstico por imagen; Nitrilos; Toluidinas/efectos adversos

Palabras clave

Multiple sclerosis; Rebound; Teriflunomide

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_sustancias_psicoativas Asunto principal: Síndrome de Abstinencia a Sustancias / Toluidinas / Crotonatos / Esclerosis Múltiple Recurrente-Remitente / Factores Inmunológicos Límite: Adult / Female / Humans Idioma: En Revista: J Neurol Sci Año: 2017 Tipo del documento: Article

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