Advances toward multifunctional cholinesterase and ß-amyloid aggregation inhibitors.
Future Med Chem
; 9(15): 1835-1854, 2017 10.
Article
en En
| MEDLINE
| ID: mdl-28925729
ABSTRACT
The emergence of a multitarget design approach in the development of new potential anti-Alzheimer's disease agents has resulted in the discovery of many multifunctional compounds focusing on various targets. Among them the largest group comprises inhibitors of both cholinesterases, with additional anti-ß-amyloid aggregation activity. This review describes recent advances in this research area and presents the most interesting compounds reported over a 2-year span (2015-2016). The majority of hybrids possess heterodimeric structures obtained by linking structurally active fragments interacting with different targets. Multipotent cholinesterase inhibitors with ß-amyloid antiaggregating activity may additionally possess antioxidative, neuroprotective or metal-chelating properties or less common features such as anti-ß-secretase or τ-antiaggregation activity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Colinesterasas
/
Péptidos beta-Amiloides
Límite:
Humans
Idioma:
En
Revista:
Future Med Chem
Año:
2017
Tipo del documento:
Article
País de afiliación:
Polonia