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[Anti-inflammation effect of Jinlingzi San in rat metabonomics based on 1H-NMR and LC-MS technology].
Shen, Shu-Jie; Shui, Su-Fang; Xiao, Bing-Kun; Yang, Jian-Yun; Huang, Rong-Qing.
Afiliación
  • Shen SJ; Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
  • Shui SF; Anhui Medical University, Hefei 230032, China.
  • Xiao BK; Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
  • Yang JY; Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
  • Huang RQ; Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
Zhongguo Zhong Yao Za Zhi ; 42(2): 363-369, 2017 Jan.
Article en Zh | MEDLINE | ID: mdl-28948745
To further explore the regulatory effect of Jinlingzi San on in vivo inflammatory mechanism during inflammatory treatment, this study adopted 1H-NMR and LC-MS technology to analyze differences in in vivo metabolites of carrageen-induce rat foot swelling model. Besides, biomarkers related to inflammation models of Jinlingzi San in SD rats were discovered to speculate the regulatory mechanism of Jinlingzi San in resisting carrageen-induce inflammation. Through the analysis of detection spectrum, we found 18 biomarkers of metabolites(citrate, pyruvate, malic acid, succinate, glutamate, lysine, tartrate, 2-oxobutyric acid, glycine, guanosine, 9-cis-retinoic acid, triphosphate, inosine 5'-diphosphate, inosine diphosphate, tripolyphosphate, inorganic triphosphate, glycerophosphocholine, 21-deoxycortisol). Relevant pathway analysis results were TCA cycle, pyruvate metabolism, glycine, serine and threonine metabolism, and dicarboxylic acid metabolism. From the metabolic network, we can see that the anti-inflammatory effect of Jinlingzi San can regulate citric acid, succinic acid and glycine content to resist oxygen free radical and reduce body damage by ROS, so as to down-regulate inflammatory factors generated from body tissues and resist inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Metabolómica / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2017 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Metabolómica / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2017 Tipo del documento: Article País de afiliación: China
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