Potential contribution of tumor-associated slan+ cells as anti-CSF-1R targets in human carcinoma.
J Leukoc Biol
; 103(3): 559-564, 2018 03.
Article
en En
| MEDLINE
| ID: mdl-28951423
ABSTRACT
The precise identification of the types and respective roles of the tumor-associated myeloid cells, which include tumor-associated MÏs (TAMs), neutrophils, dendritic cells, and myeloid-derived suppressor cells, is under intensive investigation. Although tumor-associated myeloid cells may contribute to tumor cell eradication by virtue of their effector functions, they are retained to fulfill predominantly protumorigenic roles. It follows that depletion of tumor-associated myeloid cells represents one of the currently pursued therapeutic options in advanced malignancies. In that regard, RG7155/emactuzumab, a specific anti-CSF-1R humanized Ab, has been reported recently to deplete CSF-1R+ TAMs, in association with objective clinical responses in patients with advanced cancer. Because RG7155/emactuzumab has also been shown to deplete blood non-classic CD14dim/- CD16++ monocytes, which in large part include the CD16++ slan+ monocytes, we asked whether RG7155/emactuzumab could target tumor-associated slan+ cells. In this study, we confirmed that slan+ cells localize only to metastatic tumor-draining lymph nodes, not to primary tumors or distant metastases in patients with different types of carcinoma. Notably, by cell scoring on serial sections, we found that slan+ cells represent a minor fraction of the total CSF-1R+ cell pool, suggesting that slan+ cells potentially represent minor targets of anti-CSF-1R therapy. Therefore, a protumorigenic role for slan+ cells, such as that of CSF-1R+ TAMs, based on our current data, remains questionable.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Monocitos
/
Receptor de Factor Estimulante de Colonias de Macrófagos
/
Proteínas Supresoras de Tumor
/
Macrófagos
/
Anticuerpos Monoclonales
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
J Leukoc Biol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Italia