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Oncolytic H-1 Parvovirus Shows Safety and Signs of Immunogenic Activity in a First Phase I/IIa Glioblastoma Trial.
Geletneky, Karsten; Hajda, Jacek; Angelova, Assia L; Leuchs, Barbara; Capper, David; Bartsch, Andreas J; Neumann, Jan-Oliver; Schöning, Tilman; Hüsing, Johannes; Beelte, Birgit; Kiprianova, Irina; Roscher, Mandy; Bhat, Rauf; von Deimling, Andreas; Brück, Wolfgang; Just, Alexandra; Frehtman, Veronika; Löbhard, Stephanie; Terletskaia-Ladwig, Elena; Fry, Jeremy; Jochims, Karin; Daniel, Volker; Krebs, Ottheinz; Dahm, Michael; Huber, Bernard; Unterberg, Andreas; Rommelaere, Jean.
Afiliación
  • Geletneky K; Department of Neurosurgery, University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
  • Hajda J; Coordination Centre for Clinical Trials, University Hospital, Marsilius-Arkaden, Tower West, Im Neuenheimer Feld 130.3, 69120 Heidelberg, Germany.
  • Angelova AL; Department of Tumor Virology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.
  • Leuchs B; Department of Tumor Virology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.
  • Capper D; Department of Neuropathology, University Hospital, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Bartsch AJ; Department of Neuroradiology, University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
  • Neumann JO; Department of Neurosurgery, University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
  • Schöning T; University Hospital Pharmacy, Im Neuenheimer Feld 670, 69120 Heidelberg, Germany.
  • Hüsing J; Coordination Centre for Clinical Trials, University Hospital, Marsilius-Arkaden, Tower West, Im Neuenheimer Feld 130.3, 69120 Heidelberg, Germany.
  • Beelte B; Coordination Centre for Clinical Trials, University Hospital, Marsilius-Arkaden, Tower West, Im Neuenheimer Feld 130.3, 69120 Heidelberg, Germany.
  • Kiprianova I; Department of Tumor Virology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.
  • Roscher M; Department of Tumor Virology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.
  • Bhat R; Department of Tumor Virology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.
  • von Deimling A; Department of Neuropathology, University Hospital, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Brück W; Department of Neuropathology, University Medical Center, Georg August University, 37099 Göttingen, Germany.
  • Just A; Department of Tumor Virology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.
  • Frehtman V; Department of Tumor Virology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.
  • Löbhard S; Eurofins BioPharma Product Testing, Behringstraße 6/8, 82152 Planegg, Germany.
  • Terletskaia-Ladwig E; Laboratory Prof. Dr. Gisela Enders & Colleagues, MVZ and Institute of Virology, Infectious Diseases and Epidemiology e.V., Stuttgart, Germany.
  • Fry J; ProImmune, The Magdalen Centre, Oxford Science Park, Oxford OX4 4GA, UK.
  • Jochims K; IASON Consulting, Mühlenstraße 26A, 52382 Niederzier, Germany.
  • Daniel V; Department of Transplantation Immunology, Institute of Immunology, University Hospital, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany.
  • Krebs O; Oryx GmbH & Co. KG, Marktplatz 1, 85598 Baldham, Germany.
  • Dahm M; Oryx GmbH & Co. KG, Marktplatz 1, 85598 Baldham, Germany.
  • Huber B; Oryx GmbH & Co. KG, Marktplatz 1, 85598 Baldham, Germany.
  • Unterberg A; Department of Neurosurgery, University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
  • Rommelaere J; Department of Tumor Virology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany. Electronic address: j.rommelaere@dkfz.de.
Mol Ther ; 25(12): 2620-2634, 2017 Dec 06.
Article en En | MEDLINE | ID: mdl-28967558
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Genética / Glioblastoma / Virus Oncolíticos / Viroterapia Oncolítica / Parvovirus H-1 / Vectores Genéticos Tipo de estudio: Diagnostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2017 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Genética / Glioblastoma / Virus Oncolíticos / Viroterapia Oncolítica / Parvovirus H-1 / Vectores Genéticos Tipo de estudio: Diagnostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2017 Tipo del documento: Article País de afiliación: Alemania