[DYNAMICS OF ENTEROPERITONEAL TRANSLOCATION OF MICROORGANISMS ON THE EXPERIMANTAL MODEL OF ACUTE INTESTINAL OBSTRUCTION].

ABSTRACT

The article presents an analysis of the dynamics of enteroperitoneal translocation of bacteria on the model of acute intestinal obstruction (AIO) in rats by performing an experimental study on laboratory animals. Using the proposed model of AIO we have tried to determine the level of enteroperitoneal translocation as a function of the time of the impassable obstruction. The results which presented in the article clearly demonstrate that when AIO is developing in experimental animals the greatest level of translocation was revealed on the 3rd and 5th days. Statistically significant growth of the microflora in the lumen of the intestine above the level of obturation was observed on the 1st day and the whole period of observation was maintained, and it was also revealed that the level of CFU depends on the duration of the AIO and in the abdominal cavity it increases dramatically by 7 days, compared to 1 and 3 days. However, there is no significant correlation between enteroperitoneal translocation and the level of CFU in the lumen of the intestine and abdominal cavity.