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Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform.
Theron, A; Roth, R L; Hoppe, H; Parkinson, C; van der Westhuyzen, C W; Stoychev, S; Wiid, I; Pietersen, R D; Baker, B; Kenyon, C P.
Afiliación
  • Theron A; CSIR Biosciences, Pretoria, South Africa.
  • Roth RL; CSIR Biosciences, Pretoria, South Africa.
  • Hoppe H; CSIR Biosciences, Pretoria, South Africa.
  • Parkinson C; School of Biomedical Sciences, Charles Sturt University, Orange NSW, Australia.
  • van der Westhuyzen CW; CSIR Biosciences, Pretoria, South Africa.
  • Stoychev S; CSIR Biosciences, Pretoria, South Africa.
  • Wiid I; DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.
  • Pietersen RD; DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.
  • Baker B; DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.
  • Kenyon CP; CSIR Biosciences, Pretoria, South Africa.
PLoS One ; 12(10): e0185068, 2017.
Article en En | MEDLINE | ID: mdl-28972974
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_neglected_diseases / 3_tuberculosis Asunto principal: Adenosina Monofosfato / Descubrimiento de Drogas / Glutamato-Amoníaco Ligasa / Mycobacterium tuberculosis Límite: Animals / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Sudáfrica
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_neglected_diseases / 3_tuberculosis Asunto principal: Adenosina Monofosfato / Descubrimiento de Drogas / Glutamato-Amoníaco Ligasa / Mycobacterium tuberculosis Límite: Animals / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Sudáfrica