Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathione deficiency.

Dickerhof, Nina; Pearson, John F; Hoskin, Teagan S; Berry, Luke J; Turner, Rufus; Sly, Peter D; Kettle, Anthony J

Dickerhof, Nina; Pearson, John F; Hoskin, Teagan S; Berry, Luke J; Turner, Rufus; Sly, Peter D; Kettle, Anthony J.

Afiliación

Dickerhof N; Centre for Free Radical Research, Department of Pathology, University of Otago Christchurch, Christchurch, New Zealand. Electronic address: nina.dickerhof@otago.ac.nz.
Pearson JF; Biostatistics and Computational Biology Unit, University of Otago Christchurch, Christchurch, New Zealand.
Hoskin TS; Centre for Free Radical Research, Department of Pathology, University of Otago Christchurch, Christchurch, New Zealand.
Berry LJ; Telethon Kids Institute, West Perth, Western Australia, Australia.
Turner R; Centre for Free Radical Research, Department of Pathology, University of Otago Christchurch, Christchurch, New Zealand.
Sly PD; Child Health Research Centre, University of Queensland, Brisbane, Australia.
Kettle AJ; Centre for Free Radical Research, Department of Pathology, University of Otago Christchurch, Christchurch, New Zealand.

Free Radic Biol Med ; 113: 236-243, 2017 12.

Article en En | MEDLINE | ID: mdl-28982600

Asunto(s)

Bronquiectasia/metabolismo; Fibrosis Quística/metabolismo; Glutatión/deficiencia; Pulmón/metabolismo; Neutrófilos/enzimología; Peroxidasa/metabolismo; Edad de Inicio; Alantoína/metabolismo; Bronquiectasia/patología; Líquido del Lavado Bronquioalveolar/química; Estudios de Casos y Controles; Niño; Preescolar; Fibrosis Quística/patología; Femenino; Glutatión/análogos & derivados; Glutatión/metabolismo; Disulfuro de Glutatión/metabolismo; Humanos; Lactante; Inflamación; Pulmón/patología; Masculino; Neutrófilos/metabolismo; Oxidación-Reducción; Estrés Oxidativo; Sulfonas/metabolismo

Palabras clave

Glutathione; Myeloperoxidase; Neutrophil; Neutrophil elastase; Oxidative stress; Protein S-glutathionylation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bronquiectasia / Peroxidasa / Fibrosis Quística / Glutatión / Pulmón / Neutrófilos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2017 Tipo del documento: Article

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