Prevention of preterm birth: Novel interventions for the cervix.
Semin Perinatol
; 41(8): 505-510, 2017 12.
Article
en En
| MEDLINE
| ID: mdl-28988725
ABSTRACT
Preterm birth is the leading cause of neonatal mortality and morbidity worldwide. Spontaneous preterm birth is a complex, multifactorial condition in which cervical dysfunction plays an important role in some women. Current treatment options for cervical dysfunction include cerclage and supplemental progesterone. In addition, cervical pessary is being studied in research protocols. However, cerclage, supplemental progesterone and cervical pessary have well known limitations and there is a strong need for alternate treatment options. In this review, we discuss two novel interventions to treat cervical dysfunction (1) injectable, silk protein-based biomaterials for cervical tissue augmentation (injectable cerclage) and (2) a patient-specific pessary. Three-dimensional computer simulation of the cervix is performed to provide a biomechanical rationale for the interventions. Further development of these novel interventions could lead to new treatment options for women with cervical dysfunction.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Problema de salud:
1_doencas_nao_transmissiveis
/
2_muertes_prevenibles
/
7_environmental_health
/
7_neonatal_care_health
/
7_nutrition
Asunto principal:
Pesarios
/
Incompetencia del Cuello del Útero
/
Cerclaje Cervical
/
Nacimiento Prematuro
Tipo de estudio:
Guideline
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Semin Perinatol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Países Bajos