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A comprehensive in vitro and in vivo metabolism study of hydroxysafflor yellow A.
Wu, Liang; Tang, Yuping; Shan, Chenxiao; Chai, Chuan; Zhou, Zhu; Shi, Xuqin; Ding, Ning; Wang, Jiaying; Lin, Liping; Tan, Renxiang.
Afiliación
  • Wu L; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Tang Y; Center for Drug Safety Evaluation and Research, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Shan C; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Chai C; Analytical Instrumentation Center, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Zhou Z; Analytical Instrumentation Center, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Shi X; Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA, 95211, USA.
  • Ding N; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Wang J; Center for Drug Safety Evaluation and Research, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Lin L; Center for Drug Safety Evaluation and Research, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Tan R; Center for Drug Safety Evaluation and Research, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
J Mass Spectrom ; 53(2): 99-108, 2018 Feb.
Article en En | MEDLINE | ID: mdl-29076598
As the most important marker component in Carthamus tinctorius L., hydroxysafflor yellow A (HSYA) was widely used in the prevention and treatment of cardiovascular diseases, due to its effect of improving blood supply, suppressing oxidative stress, and protecting against ischemia/reperfusion. In this paper, both an in vitro microsomal incubation and an in vivo animal experiment were conducted, along with an LC-Q-TOF/MS instrument and a 3-step protocol, to further explore the metabolism of HSYA. As a result, a total of 10 metabolites were searched and tentatively identified in plasma, urine, and feces after intravenous administration of HSYA to male rats, although no obvious biotransformation was found in the simulated rat liver microsomal system. The metabolites detected involving both phase I and phase II metabolism including dehydration, deglycosylation, methylation, and glucuronic acid conjugation. A few of the metabolites underwent more than one-step metabolic reactions, and some have not been reported before. The study would contribute to a further understanding of the metabolism of HSYA and provide scientific evidence for its pharmacodynamic mechanism research and clinical use.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinonas / Chalcona Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: J Mass Spectrom Asunto de la revista: BIOQUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinonas / Chalcona Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: J Mass Spectrom Asunto de la revista: BIOQUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China
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