Different EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report.
Thorac Cancer
; 9(1): 189-192, 2018 01.
Article
en En
| MEDLINE
| ID: mdl-29090842
ABSTRACT
Routine clinical and pathological evaluations to determine the relationship between different lesions are often not completely conclusive. Interestingly, detailed genetic analysis of tumor samples may provide important additional information and identify second primary lung cancers. In the present study, we report cases of two synchronous lung adenocarcinomas composed of two distinct pathological subtypes with different EGFR gene mutations a homozygous deletion in exon 19 of the papillary adenocarcinoma subtype and a point mutation of L858R in exon 21 of the tubular adenocarcinoma. The present report highlights the clinical importance of molecular cancer biomarkers to guide management decisions in cases involving multiple lung tumors.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores ErbB
/
Neoplasias Pulmonares
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Thorac Cancer
Año:
2018
Tipo del documento:
Article
País de afiliación:
Japón