4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma.
Brain Sci
; 7(11)2017 Nov 03.
Article
en En
| MEDLINE
| ID: mdl-29099739
ABSTRACT
This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line DAOY, with an IC50 = 58.1 nM, but does not affect the viability of noncancerous neural stem cells (NSC). 4SC-202 exposure inhibits hedgehog expression in the DAOY cell line. Furthermore, microarray analysis of human medulloblastoma patient tumors indicate significant upregulation of key targets in the Hedgehog signaling pathway and Protein Tyrosine Kinase (PTK7).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Brain Sci
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos