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The effect of pulmonary surfactant on the in vitro activity of Iclaprim against common respiratory bacterial pathogens.
Huang, David B; Duncan, Leonard R; Flamm, Robert K; Dryden, Matthew; Corey, G Ralph; Wilcox, Mark H; Torres, Antoni; File, Thomas M.
Afiliación
  • Huang DB; Motif BioSciences, NY, New York; Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address: david.huang@motifbio.com.
  • Duncan LR; JMI Laboratories, North Liberty, Iowa.
  • Flamm RK; JMI Laboratories, North Liberty, Iowa.
  • Dryden M; Department of Microbiology and Infection, Hampshire Hospitals NHS Foundation Trust, UK.
  • Corey GR; Duke University Medical Center, Durham, NC.
  • Wilcox MH; Leeds Teaching Hospitals & University of Leeds, Leeds, UK.
  • Torres A; Department of Pulmonology, Hospital Clinic of Barcelona, University of Barcelona, Institut D'investigacions August Pi I Sunyer, and Centro de Investigación Biomedica En Red-Enfermedades Respiratorias, Barcelona, Spain.
  • File TM; Summa Health, Akron, OH.
Diagn Microbiol Infect Dis ; 90(1): 64-66, 2018 Jan.
Article en En | MEDLINE | ID: mdl-29103875
The in vitro antimicrobial activity of iclaprim, a novel diaminopyrimidine, against common respiratory bacteria remained unchanged in the presence of pulmonary surfactant (Survanta®) at concentrations that greatly antagonized the antimicrobial activity of daptomycin. These results indicate that iclaprim could be a potential treatment for pneumonia caused by susceptible and multidrug resistant bacteria.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 4_TD Problema de salud: 4_pneumonia Asunto principal: Pirimidinas / Bacterias / Surfactantes Pulmonares / Neumonía Bacteriana / Antagonistas del Ácido Fólico / Antibacterianos Límite: Humans Idioma: En Revista: Diagn Microbiol Infect Dis Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 4_TD Problema de salud: 4_pneumonia Asunto principal: Pirimidinas / Bacterias / Surfactantes Pulmonares / Neumonía Bacteriana / Antagonistas del Ácido Fólico / Antibacterianos Límite: Humans Idioma: En Revista: Diagn Microbiol Infect Dis Año: 2018 Tipo del documento: Article