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Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.
Kumar, Vinit; Donthireddy, Laxminarasimha; Marvel, Douglas; Condamine, Thomas; Wang, Fang; Lavilla-Alonso, Sergio; Hashimoto, Ayumi; Vonteddu, Prashanthi; Behera, Reeti; Goins, Marlee A; Mulligan, Charles; Nam, Brian; Hockstein, Neil; Denstman, Fred; Shakamuri, Shanti; Speicher, David W; Weeraratna, Ashani T; Chao, Timothy; Vonderheide, Robert H; Languino, Lucia R; Ordentlich, Peter; Liu, Qin; Xu, Xiaowei; Lo, Albert; Puré, Ellen; Zhang, Chunsheng; Loboda, Andrey; Sepulveda, Manuel A; Snyder, Linda A; Gabrilovich, Dmitry I.
Afiliación
  • Kumar V; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
  • Donthireddy L; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
  • Marvel D; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
  • Condamine T; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
  • Wang F; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
  • Lavilla-Alonso S; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
  • Hashimoto A; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
  • Vonteddu P; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
  • Behera R; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
  • Goins MA; Helen F. Graham Cancer Center at Christiana Care Health System, Wilmington, DE, USA.
  • Mulligan C; Helen F. Graham Cancer Center at Christiana Care Health System, Wilmington, DE, USA.
  • Nam B; Helen F. Graham Cancer Center at Christiana Care Health System, Wilmington, DE, USA.
  • Hockstein N; Helen F. Graham Cancer Center at Christiana Care Health System, Wilmington, DE, USA.
  • Denstman F; Helen F. Graham Cancer Center at Christiana Care Health System, Wilmington, DE, USA.
  • Shakamuri S; Helen F. Graham Cancer Center at Christiana Care Health System, Wilmington, DE, USA.
  • Speicher DW; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
  • Weeraratna AT; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
  • Chao T; University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Vonderheide RH; University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Languino LR; Sidney Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
  • Ordentlich P; Syndax Pharmaceuticals, Inc., Waltham, MA 02451, USA.
  • Liu Q; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
  • Xu X; University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Lo A; University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
  • Puré E; University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
  • Zhang C; Department of Genetics and Pharmacogenomics, MRL, Merck & Co., Inc., Boston, MA 02115, USA.
  • Loboda A; Department of Genetics and Pharmacogenomics, MRL, Merck & Co., Inc., Boston, MA 02115, USA.
  • Sepulveda MA; Janssen R&D, Spring House, PA 19477, USA.
  • Snyder LA; Janssen R&D, Spring House, PA 19477, USA.
  • Gabrilovich DI; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address: dgabrilovich@wistar.org.
Cancer Cell ; 32(5): 654-668.e5, 2017 11 13.
Article en En | MEDLINE | ID: mdl-29136508
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Monocitos / Receptor de Factor Estimulante de Colonias de Macrófagos / Fibroblastos Asociados al Cáncer / Células Supresoras de Origen Mieloide / Neoplasias Experimentales Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Monocitos / Receptor de Factor Estimulante de Colonias de Macrófagos / Fibroblastos Asociados al Cáncer / Células Supresoras de Origen Mieloide / Neoplasias Experimentales Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos