Age-induced and photoinduced changes in gene expression profiles in facial skin of Caucasian females across 6 decades of age.
J Am Acad Dermatol
; 78(1): 29-39.e7, 2018 Jan.
Article
en En
| MEDLINE
| ID: mdl-29146147
ABSTRACT
BACKGROUND:
Intrinsic and extrinsic factors, including ultraviolet irradiation, lead to visible signs of skin aging.OBJECTIVE:
We evaluated molecular changes occurring in photoexposed and photoprotected skin of white women 20 to 74 years of age, some of whom appeared substantially younger than their chronologic age.METHODS:
Histologic and transcriptomics profiling were conducted on skin biopsy samples of photoexposed (face and dorsal forearm) or photoprotected (buttocks) body sites from 158 women. 23andMe genotyping determined genetic ancestry.RESULTS:
Gene expression and ontologic analysis revealed progressive changes from the 20s to the 70s in pathways related to oxidative stress, energy metabolism, senescence, and epidermal barrier; these changes were accelerated in the 60s and 70s. The gene expression patterns from the subset of women who were younger-appearing were similar to those in women who were actually younger.LIMITATIONS:
Broader application of these findings (eg, across races and Fitzpatrick skin types) will require further studies.CONCLUSIONS:
This study demonstrates a wide range of molecular processes in skin affected by aging, providing relevant targets for improving the condition of aging skin at different life stages and defining a molecular pattern of epidermal gene expression in women who appear younger than their chronologic age.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rayos Ultravioleta
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Envejecimiento de la Piel
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Predisposición Genética a la Enfermedad
Tipo de estudio:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
2018
Tipo del documento:
Article