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The role of epigenetics in cardiovascular health and ageing: A focus on physical activity and nutrition.
Wallace, Robert G; Twomey, Laura C; Custaud, Marc-Antoine; Turner, Jonathan D; Moyna, Niall; Cummins, Philip M; Murphy, Ronan P.
Afiliación
  • Wallace RG; School of Health & Human Performance, Dublin City University, Ireland; Centre for Preventive Medicine, Dublin City University, Ireland. Electronic address: robert.wallace6@mail.dcu.ie.
  • Twomey LC; School of Health & Human Performance, Dublin City University, Ireland; Centre for Preventive Medicine, Dublin City University, Ireland.
  • Custaud MA; Centre de Recherche Clinique du CHU d'Angers, France.
  • Turner JD; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, L-4354, Luxembourg.
  • Moyna N; School of Health & Human Performance, Dublin City University, Ireland.
  • Cummins PM; Centre for Preventive Medicine, Dublin City University, Ireland; School of Biotechnology, Dublin City University, Ireland.
  • Murphy RP; School of Health & Human Performance, Dublin City University, Ireland; Centre for Preventive Medicine, Dublin City University, Ireland.
Mech Ageing Dev ; 174: 76-85, 2018 09.
Article en En | MEDLINE | ID: mdl-29155255
ABSTRACT
The cardiovascular system is responsible for transport of blood and nutrients to tissues, and is pivotal to the physiological health and longevity. Epigenetic modification is a natural, age-associated process resulting in highly contextualised gene expression with clear implications for cell differentiation and disease onset. Biological/epigenetic age is independent of chronological age, constituting a highly reflective snapshot of an individual's overall health. Accelerated vascular ageing is of major concern, effectively lowering disease threshold. Age-related chronic illness involves a complex interplay between many biological processes and is modulated by non-modifiable and modifiable risk factors. These alter the static genome by a number of epigenetic mechanisms, which change gene expression in an age and lifestyle dependent manner. This 'epigenetic drift' impacts health and contributes to the etiology of chronic illness. Lifestyle factors may cause acceleration of this epigenetic "clock", pre-disposing individuals to cardiovascular disease. Nutrition and physical activity are modifiable lifestyle choices, synergistically contributing to cardiovascular health. They represent a powerful potential epigenetic intervention point for effective cardiovascular protective and management strategies. Thus, together with traditional risk factors, monitoring the epigenetic signature of ageing may prove beneficial for tailoring lifestyle to fit biology - supporting the increasingly popular concept of "ageing well".
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Enfermedades Cardiovasculares / Ejercicio Físico / Epigénesis Genética / Fenómenos Fisiológicos Nutricionales del Anciano Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Mech Ageing Dev Año: 2018 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Enfermedades Cardiovasculares / Ejercicio Físico / Epigénesis Genética / Fenómenos Fisiológicos Nutricionales del Anciano Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Mech Ageing Dev Año: 2018 Tipo del documento: Article
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