Quantitative Imaging for Targeted Radionuclide Therapy Dosimetry - Technical Review.
Theranostics
; 7(18): 4551-4565, 2017.
Article
en En
| MEDLINE
| ID: mdl-29158844
ABSTRACT
Targeted radionuclide therapy (TRT) is a promising technique for cancer therapy. However, in order to deliver the required dose to the tumor, minimize potential toxicity in normal organs, as well as monitor therapeutic effects, it is important to assess the individualized internal dosimetry based on patient-specific data. Advanced imaging techniques, especially radionuclide imaging, can be used to determine the spatial distribution of administered tracers for calculating the organ-absorbed dose. While planar scintigraphy is still the mainstream imaging method, SPECT, PET and bremsstrahlung imaging have promising properties to improve accuracy in quantification. This article reviews the basic principles of TRT and discusses the latest development in radionuclide imaging techniques for different theranostic agents, with emphasis on their potential to improve personalized TRT dosimetry.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Radiometría
Límite:
Humans
Idioma:
En
Revista:
Theranostics
Año:
2017
Tipo del documento:
Article
País de afiliación:
China