Therapeutic prospects of microRNAs in cancer treatment through nanotechnology.
Drug Deliv Transl Res
; 8(1): 97-110, 2018 Feb.
Article
en En
| MEDLINE
| ID: mdl-29185148
ABSTRACT
MicroRNAs (miRNAs) represent a new class of diagnostic and prognostic biomarker as well as new therapeutic targets in cancer therapy. miRNAs are gaining significant interest due to extensive advancements in knowledge since their discovery and, more recently, their translational application as therapeutic moieties and targets in the management of disease. miRNAs used in the treatment of cancer would position them as a new class of emerging therapeutic agents. Indeed, numerous candidate miRNAs have been identified as having therapeutic application in the treatment of cancer, but there is still much to learn about how to transform these into effective, patient-compliant, and targeted drug delivery systems. In this mini review, we discuss the utility and potential of nanotechnology in miRNA formulation and delivery with particular emphasis on cancer, including their role in conferring multidrug resistance and metastatic capacity. This review benefits both the formulation and biological scientists in understanding and exploring the new vistas of miRNA delivery using nanotechnology in the cancer clinically.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
MicroARNs
/
Nanopartículas
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Deliv Transl Res
Año:
2018
Tipo del documento:
Article
País de afiliación:
India