Suppression of autophagy in the brain of transgenic mice with overexpression of Ð53Ð¢-mutant &#945;-synuclein as an early event at synucleinopathy progression.

Pupyshev, Alexander B; Korolenko, Tatiana A; Akopyan, Anna A; Amstislavskaya, Tamara G; Tikhonova, Maria A

Suppression of autophagy in the brain of transgenic mice with overexpression of Ð53Ð¢-mutant α-synuclein as an early event at synucleinopathy progression.

Pupyshev, Alexander B; Korolenko, Tatiana A; Akopyan, Anna A; Amstislavskaya, Tamara G; Tikhonova, Maria A.

Afiliación

Pupyshev AB; Federal State Budgetary Scientific Institution "Scientific Research Institute of Physiology and Basic Medicine" (SRIPhBM), Novosibirsk 630117, Russia. Electronic address: pupyshevab@physiol.ru.
Korolenko TA; Federal State Budgetary Scientific Institution "Scientific Research Institute of Physiology and Basic Medicine" (SRIPhBM), Novosibirsk 630117, Russia.
Akopyan AA; Federal State Budgetary Scientific Institution "Scientific Research Institute of Physiology and Basic Medicine" (SRIPhBM), Novosibirsk 630117, Russia.
Amstislavskaya TG; Federal State Budgetary Scientific Institution "Scientific Research Institute of Physiology and Basic Medicine" (SRIPhBM), Novosibirsk 630117, Russia; Novosibirsk State University, Novosibirsk 630090, Russia.
Tikhonova MA; Federal State Budgetary Scientific Institution "Scientific Research Institute of Physiology and Basic Medicine" (SRIPhBM), Novosibirsk 630117, Russia; Novosibirsk State University, Novosibirsk 630090, Russia.

Neurosci Lett ; 672: 140-144, 2018 04 13.

Article en En | MEDLINE | ID: mdl-29203207

Asunto(s)

Autofagia/genética; Cuerpo Estriado/metabolismo; Lóbulo Frontal/metabolismo; Enfermedad de Parkinson/genética; Sustancia Negra/metabolismo; alfa-Sinucleína/genética; Animales; Modelos Animales de Enfermedad; Progresión de la Enfermedad; Neuronas Dopaminérgicas/metabolismo; Ratones; Ratones Transgénicos; Enfermedad de Parkinson/metabolismo; Tirosina 3-Monooxigenasa/metabolismo; alfa-Sinucleína/metabolismo

Palabras clave

Animal model; Autophagy; LC3-II; Mouse; Parkinson's disease; Ð53Ð¢-mutant α-synuclein

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Autofagia / Sustancia Negra / Cuerpo Estriado / Alfa-Sinucleína / Lóbulo Frontal Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2018 Tipo del documento: Article

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