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Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers.
de Taeye, Steven W; de la Peña, Alba Torrents; Vecchione, Andrea; Scutigliani, Enzo; Sliepen, Kwinten; Burger, Judith A; van der Woude, Patricia; Schorcht, Anna; Schermer, Edith E; van Gils, Marit J; LaBranche, Celia C; Montefiori, David C; Wilson, Ian A; Moore, John P; Ward, Andrew B; Sanders, Rogier W.
Afiliación
  • de Taeye SW; From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • de la Peña AT; From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • Vecchione A; From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • Scutigliani E; From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • Sliepen K; From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • Burger JA; From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • van der Woude P; From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • Schorcht A; From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • Schermer EE; From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • van Gils MJ; From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • LaBranche CC; the Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710.
  • Montefiori DC; the Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710.
  • Wilson IA; the Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery, Scripps Research Institute, La Jolla, California 92037, and.
  • Moore JP; the Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021.
  • Ward AB; the Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery, Scripps Research Institute, La Jolla, California 92037, and.
  • Sanders RW; From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands, r.w.sanders@amc.uva.nl.
J Biol Chem ; 293(5): 1688-1701, 2018 02 02.
Article en En | MEDLINE | ID: mdl-29222332
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anticuerpos Anti-VIH / Proteína gp120 de Envoltorio del VIH / Multimerización de Proteína / Anticuerpos Neutralizantes / Epítopos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anticuerpos Anti-VIH / Proteína gp120 de Envoltorio del VIH / Multimerización de Proteína / Anticuerpos Neutralizantes / Epítopos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos