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The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.
Kosak, Urban; Brus, Boris; Knez, Damijan; Zakelj, Simon; Trontelj, Jurij; Pislar, Anja; Sink, Roman; Jukic, Marko; Zivin, Marko; Podkowa, Adrian; Nachon, Florian; Brazzolotto, Xavier; Stojan, Jure; Kos, Janko; Coquelle, Nicolas; Salat, Kinga; Colletier, Jacques-Philippe; Gobec, Stanislav.
Afiliación
  • Kosak U; Faculty of Pharmacy, University of Ljubljana , Askerceva 7, 1000 Ljubljana, Slovenia.
  • Brus B; Faculty of Pharmacy, University of Ljubljana , Askerceva 7, 1000 Ljubljana, Slovenia.
  • Knez D; Faculty of Pharmacy, University of Ljubljana , Askerceva 7, 1000 Ljubljana, Slovenia.
  • Zakelj S; Faculty of Pharmacy, University of Ljubljana , Askerceva 7, 1000 Ljubljana, Slovenia.
  • Trontelj J; Faculty of Pharmacy, University of Ljubljana , Askerceva 7, 1000 Ljubljana, Slovenia.
  • Pislar A; Faculty of Pharmacy, University of Ljubljana , Askerceva 7, 1000 Ljubljana, Slovenia.
  • Sink R; Faculty of Pharmacy, University of Ljubljana , Askerceva 7, 1000 Ljubljana, Slovenia.
  • Jukic M; Faculty of Pharmacy, University of Ljubljana , Askerceva 7, 1000 Ljubljana, Slovenia.
  • Zivin M; Institute of Pathological Physiology, Faculty of Medicine, University of Ljubljana , Vrazov trg 2, 1000 Ljubljana, Slovenia.
  • Podkowa A; Faculty of Pharmacy, Jagiellonian University , Medyczna 9 St., 30-688 Krakow, Poland.
  • Nachon F; Institut de Recherche Biomédicale des Armées , 91223 Brétigny sur Orge, France.
  • Brazzolotto X; Institut de Recherche Biomédicale des Armées , 91223 Brétigny sur Orge, France.
  • Stojan J; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana , Vrazov trg 2, 1000 Ljubljana, Slovenia.
  • Kos J; Faculty of Pharmacy, University of Ljubljana , Askerceva 7, 1000 Ljubljana, Slovenia.
  • Coquelle N; University Grenoble Alpes, and CNRS and CEA, IBS , F-38044 Grenoble, France.
  • Salat K; Faculty of Pharmacy, Jagiellonian University , Medyczna 9 St., 30-688 Krakow, Poland.
  • Colletier JP; University Grenoble Alpes, and CNRS and CEA, IBS , F-38044 Grenoble, France.
  • Gobec S; Faculty of Pharmacy, University of Ljubljana , Askerceva 7, 1000 Ljubljana, Slovenia.
J Med Chem ; 61(1): 119-139, 2018 01 11.
Article en En | MEDLINE | ID: mdl-29227101
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Butirilcolinesterasa / Diseño de Fármacos / Inhibidores de la Colinesterasa Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Eslovenia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Butirilcolinesterasa / Diseño de Fármacos / Inhibidores de la Colinesterasa Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Eslovenia