[A case of myasthenia-like symptoms induced by cibenzoline overdosage].
Rinsho Shinkeigaku
; 58(1): 41-44, 2018 Jan 26.
Article
en Ja
| MEDLINE
| ID: mdl-29269691
ABSTRACT
The present patient was an 87-year-old man who had been taking cibenzoline for tachyarrhythmia. Five years after initiation of administration, he was referred to our hospital for ptosis that worsened from midday, as well as weakness of the facial and limb muscles. He tested negative for anti-acetylcholine receptor antibody but positive in the edrophonium test, suggesting that he had myasthenia gravis. He was admitted to our hospital 3 years later due to worsening symptoms of ptosis and muscle weakness. He had hypoglycemia, cardiac conduction defect, and renal dysfunction. In addition, blood concentration of cibenzoline was markedly high (1,850â
ng/ml). We terminated the administration of cibenzoline, after which the patient's neurologic symptoms improved. Our findings suggest that cibenzoline toxicity must be considered in differentiating myasthenia gravis when a patient also presents with renal dysfunction.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sobredosis de Droga
/
Imidazoles
/
Miastenia Gravis
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Aged80
/
Humans
/
Male
Idioma:
Ja
Revista:
Rinsho Shinkeigaku
Año:
2018
Tipo del documento:
Article