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Reconstructing an African haploid genome from the 18th century.
Jagadeesan, Anuradha; Gunnarsdóttir, Ellen D; Ebenesersdóttir, S Sunna; Guðmundsdóttir, Valdis B; Thordardottir, Elisabet Linda; Einarsdóttir, Margrét S; Jónsson, Hákon; Dugoujon, Jean-Michel; Fortes-Lima, Cesar; Migot-Nabias, Florence; Massougbodji, Achille; Bellis, Gil; Pereira, Luisa; Másson, Gísli; Kong, Augustine; Stefánsson, Kári; Helgason, Agnar.
Afiliación
  • Jagadeesan A; deCODE Genetics/Amgen, Reykjavik, Iceland.
  • Gunnarsdóttir ED; Department of Anthropology, University of Iceland, Reykjavik, Iceland.
  • Ebenesersdóttir SS; deCODE Genetics/Amgen, Reykjavik, Iceland.
  • Guðmundsdóttir VB; deCODE Genetics/Amgen, Reykjavik, Iceland.
  • Thordardottir EL; Department of Anthropology, University of Iceland, Reykjavik, Iceland.
  • Einarsdóttir MS; deCODE Genetics/Amgen, Reykjavik, Iceland.
  • Jónsson H; Department of Anthropology, University of Iceland, Reykjavik, Iceland.
  • Dugoujon JM; deCODE Genetics/Amgen, Reykjavik, Iceland.
  • Fortes-Lima C; deCODE Genetics/Amgen, Reykjavik, Iceland.
  • Migot-Nabias F; Department of Anthropology, University of Iceland, Reykjavik, Iceland.
  • Massougbodji A; deCODE Genetics/Amgen, Reykjavik, Iceland.
  • Bellis G; Laboratoire d'Eco-Anthropologie et Ethnobiologie, Equipe d'Anthropologie Evolutive, UMR 7206, Centre National de la Recherche Scientifique (CNRS) et Université Diderot Paris 7, Paris, France.
  • Pereira L; Laboratoire d'Eco-Anthropologie et Ethnobiologie, Equipe d'Anthropologie Evolutive, UMR 7206, Centre National de la Recherche Scientifique (CNRS) et Université Diderot Paris 7, Paris, France.
  • Másson G; Institut de Recherche pour le Développement, UMR D216 MERIT (Mère et enfant face aux infections tropicales), Paris, France.
  • Kong A; COMUE Sorbonne Paris Cité, Faculté de Pharmacie, Université Paris Descartes, Paris, France.
  • Stefánsson K; Centre d'Etude et de Recherche sur le Paludisme Associé à la Grossesse et l'Enfance (CERPAGE), Cotonou, Benin.
  • Helgason A; Laboratoire de Parasitologie, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin.
Nat Genet ; 50(2): 199-205, 2018 02.
Article en En | MEDLINE | ID: mdl-29335549
ABSTRACT
A genome is a mosaic of chromosome fragments from ancestors who existed some arbitrary number of generations earlier. Here, we reconstruct the genome of Hans Jonatan (HJ), born in the Caribbean in 1784 to an enslaved African mother and European father. HJ migrated to Iceland in 1802, married and had two children. We genotyped 182 of his 788 descendants using single-nucleotide polymorphism (SNP) chips and whole-genome sequenced (WGS) 20 of them. Using these data, we reconstructed 38% of HJ's maternal genome and inferred that his mother was from the region spanned by Benin, Nigeria and Cameroon.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linaje / Genoma Humano / Población Negra / Personas Esclavizadas / Haploidia Límite: Humans / Male País/Región como asunto: Caribe / Europa Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Islandia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linaje / Genoma Humano / Población Negra / Personas Esclavizadas / Haploidia Límite: Humans / Male País/Región como asunto: Caribe / Europa Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Islandia