Three-season effectiveness of inactivated influenza vaccine in preventing influenza illness and hospitalization in children in Japan, 2013-2016.
Vaccine
; 36(8): 1063-1071, 2018 02 14.
Article
en En
| MEDLINE
| ID: mdl-29361343
ABSTRACT
OBJECTIVES:
We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children 6â¯months to 15â¯years of age in 2015/16 season. In addition, based on the data obtained during the three seasons from 2013 to 2016, we estimated the three-season VE in preventing influenza illness and hospitalization.METHODS:
Our study was conducted according to a test-negative case-control design (TNCC) and as a case-control study based on influenza rapid diagnostic test results.RESULTS:
During 2015/16 season, the quadrivalent IIV was first used in Japan. The adjusted VE in preventing influenza illness was 49% (95% confidence interval [CI] 42-55%) against any type of influenza, 57% (95% CI 50-63%) against influenza A and 34% (95% CI 23-44%) against influenza B. The 3-season adjusted VE was 45% (95% CI 41-49%) against influenza virus infection overall (Nâ¯=â¯12,888), 51% (95% CI 47-55%) against influenza A (Nâ¯=â¯10,410), and 32% (95% CI 24-38%) against influenza B (Nâ¯=â¯9232). An analysis by age groups showed low or no significant VE in infants or adolescents. By contrast, VE was highest in the young group (1-5â¯years old) and declined with age thereafter. The 3-season adjusted VE in preventing hospitalization as determined in a case-control study was 52% (95% CI 42-60%) for influenza A and 28% (95% CI 4-46%) for influenza B, and by TNCC design, it was 54% (95% CI 41-65%) for influenza A and 34% (95% CI 6-54%) for influenza B.CONCLUSION:
We demonstrated not only VE in preventing illness, but also VE in preventing hospitalization based on much larger numbers of children than previous studies.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
Problema de salud:
1_doencas_transmissiveis
/
2_enfermedades_transmissibles
Asunto principal:
Virus de la Influenza A
/
Virus de la Influenza B
/
Vacunas contra la Influenza
/
Gripe Humana
/
Epidemias
/
Hospitalización
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
País/Región como asunto:
Asia
Idioma:
En
Revista:
Vaccine
Año:
2018
Tipo del documento:
Article