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Antioxidant activity and anticancer effect of ethanolic and aqueous extracts of the roots of Ficus beecheyana and their phenolic components.
Yen, Gow-Chin; Chen, Cheng-Shih; Chang, Wei-Tang; Wu, Mei-Fang; Cheng, Feng-Tsung; Shiau, Duen-Kai; Hsu, Chin-Lin.
Afiliación
  • Yen GC; Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan.
  • Chen CS; Department of Industrial Engineering and Systems Management, Feng-Chia University, Taichung, Taiwan.
  • Chang WT; School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.
  • Wu MF; Department of Industrial Engineering and Systems Management, Feng-Chia University, Taichung, Taiwan.
  • Cheng FT; Department of Industrial Engineering and Systems Management, Feng-Chia University, Taichung, Taiwan.
  • Shiau DK; Department of Industrial Engineering and Systems Management, Feng-Chia University, Taichung, Taiwan.
  • Hsu CL; Department of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, Taichung, Taiwan.
J Food Drug Anal ; 26(1): 182-192, 2018 01.
Article en En | MEDLINE | ID: mdl-29389554
This study aimed to investigate the antioxidant and anticancer effects of ethanolic and aqueous extracts of the roots of Ficus beecheyana (EERFB and AERFB) and their phenolic components. In this study, total phenolic content and antioxidant activity of EERFB were higher than those of AERFB. Major phenolic compounds in the extracts were gallic acid, p-hydroxybenzoic acid, caffeic acid, chlorogenic acid, p-coumaric acid, and rutin; which were identified by high-performance liquid chromatography. Flow cytometric analysis of HL-60 cells exposed to EERFB showed that the percentage of apoptotic cells increased in a dose-dependent manner. EERFB treatment resulted in the loss of mitochondrial membrane potential and induced the apoptosis of HL-60 cells through a Fas- and mitochondrial-mediated pathway. Finally, pretreatment with general caspase-9/-3 inhibitors prevented EERFB from inhibiting cell viability in HL-60 cells. Our finding suggests that EERFB is an agent that may have antioxidant activity and inhibit the growth of cancer cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Extractos Vegetales / Raíces de Plantas / Ficus / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Food Drug Anal Año: 2018 Tipo del documento: Article País de afiliación: Taiwán

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Extractos Vegetales / Raíces de Plantas / Ficus / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Food Drug Anal Año: 2018 Tipo del documento: Article País de afiliación: Taiwán
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