Skin reactions induced by trimetrexate, an analog of methotrexate.
Invest New Drugs
; 4(2): 159-63, 1986.
Article
en En
| MEDLINE
| ID: mdl-2942517
ABSTRACT
We have observed three forms of skin toxicity induced by the new antifol trimetrexate in a Phase I trial. They are radiation recall, cellulitis at the infusion site, and generalized skin eruptions with erythroderma. A total of 25 episodes of some form of skin reaction occurred in 31 patients. The generalized eruption began about four days after drug administration and cleared within a week. The mechanism of skin toxicity of trimetrexate and other antifols is unknown.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinazolinas
/
Enfermedades de la Piel
Límite:
Humans
Idioma:
En
Revista:
Invest New Drugs
Año:
1986
Tipo del documento:
Article