The PHD1 oxygen sensor in health and disease.
J Physiol
; 596(17): 3899-3913, 2018 09.
Article
en En
| MEDLINE
| ID: mdl-29435987
ABSTRACT
The hypoxia-inducible factor (HIF) co-ordinates the adaptive transcriptional response to hypoxia in metazoan cells. The hypoxic sensitivity of HIF is conferred by a family of oxygen-sensing enzymes termed HIF hydroxylases. This family consists of three prolyl hydroxylases (PHD1-3) and a single asparagine hydroxylase termed factor inhibiting HIF (FIH). It has recently become clear that HIF hydroxylases are functionally non-redundant and have discrete but overlapping physiological roles. Furthermore, altered abundance or activity of these enzymes is associated with a number of pathologies. Pharmacological HIF-hydroxylase inhibitors have recently proven to be both tolerated and therapeutically effective in patients. In this review, we focus on the physiology, pathophysiology and therapeutic potential of the PHD1 isoform, which has recently been implicated in diseases including inflammatory bowel disease, ischaemia and cancer.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxígeno
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Técnicas Biosensibles
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Enfermedades Inflamatorias del Intestino
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Prolina Dioxigenasas del Factor Inducible por Hipoxia
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Isquemia
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Hipoxia
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Neoplasias
Límite:
Animals
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Humans
Idioma:
En
Revista:
J Physiol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Alemania