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Characterization of Articaine-Loaded Poly(ε-caprolactone) Nanocapsules and Solid Lipid Nanoparticles in Hydrogels for Topical Formulations.
Melo, Nathalie Ferreira Silva de; Campos, Estefânia Vangelie Ramos; Franz-Montan, Michelle; Paula, Eneida de; Silva, Camila Morais Gonçalves da; Maruyama, Cíntia Rodrigues; Stigliani, Tatiane Pasquoto; Lima, Renata de; Araújo, Daniele Ribeiro de; Fraceto, Leonardo Fernandes.
Afiliación
  • Melo NFS; Department of Immunology and Molecular Biology, São Leopoldo Mandic Research Institute, Campinas, 13045755, SP, Brazil.
  • Campos EVR; Department of Environmental Engineering, São Paulo State University, Sorocaba, 18180000, SP, Brazil.
  • Franz-Montan M; Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, 13414018, SP, Brazil.
  • Paula E; Department of Biochemistry, State University of Campinas, Campinas, 13083862, SP, Brazil.
  • Silva CMGD; Department of Biochemistry, State University of Campinas, Campinas, 13083862, SP, Brazil.
  • Maruyama CR; Department of Environmental Engineering, São Paulo State University, Sorocaba, 18180000, SP, Brazil.
  • Stigliani TP; Department of Biotechnology, University of Sorocaba, Sorocaba, 18023-000, SP, Brazil.
  • Lima R; Department of Biotechnology, University of Sorocaba, Sorocaba, 18023-000, SP, Brazil.
  • Araújo DR; Federal University of ABC, Santo André, 09210580, SP, Brazil.
  • Fraceto LF; Department of Environmental Engineering, São Paulo State University, Sorocaba, 18180000, SP, Brazil.
J Nanosci Nanotechnol ; 18(6): 4428-4438, 2018 Jun 01.
Article en En | MEDLINE | ID: mdl-29442800
ABSTRACT
This work describes the development of poly-ε-caprolactone nanocapsules (PCL-NC) and solid lipid nanoparticles (SLN) aiming delivery for articaine (ATC), in order to improve its chemical stability in semi-solid preparations looking forward their use for skin delivery. The nanoparticles were characterized by size, polydispersity index, and pH. Cellular viability was evaluated using the MTT test and the in vitro release kinetics was determined using a two-compartment model. The hydrogels with nanoparticle suspensions were characterized considering their rheological aspects and in vitro permeation across artificial membranes. Colloidal stability was satisfactory, since the formulations did not present major alterations during 120 days. High ATC encapsulation was achieved (78% for PCL-NC and 65% for SLN). The release profile of PCL-NC-ATC was slower, compared to the free molecule and SLN-ATC. MTT experiments showed the nanosystems were capable to increase cellular viability compared with free ATC. The hydrogels showed good consistency, homogeneity, and stability and presented pseudoplastic behavior with thixotropy, improving drug efficacy in clinical applications. The gel based on PCL-NC showed faster onset of activity and flux of 35.68 ± 1.98 µg/cm2/h, which then continued for up to 8 h. This study opens up prospects for employment of nanoparticulate systems for modified release of ATC.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Carticaína / Nanocápsulas / Anestésicos Locales Idioma: En Revista: J Nanosci Nanotechnol Año: 2018 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Carticaína / Nanocápsulas / Anestésicos Locales Idioma: En Revista: J Nanosci Nanotechnol Año: 2018 Tipo del documento: Article País de afiliación: Brasil
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