Accurate analytic solution of chemical master equations for gene regulation networks in a single cell.
Phys Rev E
; 97(1-1): 012412, 2018 Jan.
Article
en En
| MEDLINE
| ID: mdl-29448337
ABSTRACT
Studying gene regulation networks in a single cell is an important, interesting, and hot research topic of molecular biology. Such process can be described by chemical master equations (CMEs). We propose a Hamilton-Jacobi equation method with finite-size corrections to solve such CMEs accurately at the intermediate region of switching, where switching rate is comparable to fast protein production rate. We applied this approach to a model of self-regulating proteins [H. Ge et al., Phys. Rev. Lett. 114, 078101 (2015)PRLTAO0031-900710.1103/PhysRevLett.114.078101] and found that as a parameter related to inducer concentration increases the probability of protein production changes from unimodal to bimodal, then to unimodal, consistent with phenotype switching observed in a single cell.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Redes Reguladoras de Genes
/
Modelos Biológicos
Idioma:
En
Revista:
Phys Rev E
Año:
2018
Tipo del documento:
Article
País de afiliación:
Taiwán