Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis.
Mult Scler Relat Disord
; 21: 24-29, 2018 Apr.
Article
en En
| MEDLINE
| ID: mdl-29454153
ABSTRACT
BACKGROUND:
Muscle carnosine is related to contractile function (Ca++ handling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS.METHODS:
Tibialis anterior muscle carnosine was measured in an animal MS model (EAE, experimental autoimmune encephalomyelitis, n = 40) and controls (CON, n = 40) before and after exercise training (EAEEX, CONEX, 10d, 1â¯h/d, 24â¯m/min treadmill running) or sedentary conditions (EAESED, CONSED). Human m. vastus lateralis carnosine of healthy controls (HC, n = 22) and MS patients (n = 24) was measured.RESULTS:
EAE muscle carnosine levels were decreased (p < .0001) by ~ 40% to ~ 64% at 10d and 17d following EAE induction (respectively) regardless of exercise (p = .823). Similarly, human MS muscle carnosine levels were decreased (- 25%, p = .03).CONCLUSION:
Muscle carnosine concentrations in an animal MS model and MS patients are substantially reduced. In EAE exercise therapy does not restore this.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carnosina
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Músculo Esquelético
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Encefalomielitis Autoinmune Experimental
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Esclerosis Múltiple
Tipo de estudio:
Clinical_trials
Límite:
Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Mult Scler Relat Disord
Año:
2018
Tipo del documento:
Article