Association of N-acetyltransferase-2 and glutathione S-transferase polymorphisms with idiopathic male infertility in Vietnam male subjects.
Chem Biol Interact
; 286: 11-16, 2018 Apr 25.
Article
en En
| MEDLINE
| ID: mdl-29505746
ABSTRACT
N-acetyltransferase-2 (NAT2) and Glutathione S-transferases (GSTs) are phase-II xenobiotic metabolizing enzymes participating in detoxification of toxic arylamines, aromatic amines, hydrazines and reactive oxygen species (ROS), which are produced under oxidative and electrophile stresses. The purpose of this research was to investigate whether two common single-nucleotide polymorphisms (SNP) of NAT2 (rs1799929, rs1799930) and GSTP1 (rs1138272, rs1695) associated with susceptibility to idiopathic male infertility. A total 300 DNA samples (150 infertile patients and 150 healthy control) were genotyped for the polymorphisms by ARMS - PCR. We revealed a significant association between the NAT2 variant genotypes (CT + TT (rs1799929), (OR 3.74; p < 0.001)) and (GA + AA (rs1799930), (OR 3.75; p < 0.001)) or GSTP1 variant genotypes (GA + AA (rs1695), (OR 5.11; p < 0,001)) and (CT + TT (rs1138272), (OR 7.42; p < 0,001) with idiopathic infertility risk. Our findings rate the effect of single-nucleotide polymorphisms of GSTP1 and/or NAT2 in modulation of the risk of male infertility in subjects from Vietnam. This pilot study is the first (as far as we know) to reveal that polymorphisms of NAT2 (rs1799929, rs1799930) and GSTP1 (rs1138272, rs1695) are some novel genetic markers for susceptibility to idiopathic male infertility.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arilamina N-Acetiltransferasa
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Pueblo Asiatico
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Gutatión-S-Transferasa pi
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Infertilidad Masculina
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Chem Biol Interact
Año:
2018
Tipo del documento:
Article