Mycobacterial nucleoid associated proteins: An added dimension in gene regulation.
Tuberculosis (Edinb)
; 108: 169-177, 2018 01.
Article
en En
| MEDLINE
| ID: mdl-29523320
ABSTRACT
Nucleoid associated proteins (NAPs) are known organisers of chromosomal structure and regulators of transcriptional expression. The number of proposed NAPs in mycobacteria are significantly lower than the number identified in other organisms. An interesting feature of mycobacterial NAPs is their low sequence similarity with those in other species, a property that has hindered their identification. In this review, we discuss the current evidence for the proposed classification of six mycobacterial proteins, Lsr2, EspR, mIHF, HupB, MDP2 and NapM, as NAPs in mycobacterial species with an emphasis on their roles in modulating chromosome structure and transcriptional regulation. In addition, we highlight the technical difficulties associated with investigating and providing evidence for the classification of proteins as NAPs in mycobacteria. We also address the role of mycobacterial NAPs as mediators of stress responses and highlight the recent developments aimed at targeting NAP-DNA interactions for the development of novel anti-TB drugs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_tuberculosis
Asunto principal:
Proteínas Bacterianas
/
Regulación Bacteriana de la Expresión Génica
/
Mycobacterium tuberculosis
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Tuberculosis (Edinb)
Año:
2018
Tipo del documento:
Article