The Incidence of Pediatric Invasive Bacterial Diseases in Nippon Medical School Chiba Hokusoh Hospital before and after the Introduction of Conjugate Vaccines.
J Nippon Med Sch
; 85(1): 34-38, 2018.
Article
en En
| MEDLINE
| ID: mdl-29540644
ABSTRACT
The introduction of the Haemophilus influenzae type b (Hib) vaccine and the 7-valent pneumococcal conjugate vaccine (PCV7) has led to dramatic reductions in cases of invasive H. influenzae disease and invasive pneumococcal disease (IPD). After the introduction of the PCV7 and the 13-valent pneumococcal conjugate vaccine (PCV13), the number of children with IPD markedly decreased in our hospital. However, since 2015, three children with IPD have been admitted to our hospital. We analyzed the serotype, multilocus sequence type, and antimicrobial susceptibility of Streptococcus pneumoniae strains isolated in these newly diagnosed cases. The strains were serotypes 7F and 12F. In addition, we analyzed the incidence of invasive bacterial disease before and after the introduction of conjugate vaccines and found no change in the incidences. We found that cases of IPD and invasive H. influenzae disease clearly decreased following the introduction of the PCV7, the PCV13, and the Hib vaccine, as well as disease caused by antibiotic-resistant strains.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
3_ND
/
4_TD
Problema de salud:
1_doencas_transmissiveis
/
3_zoonosis
/
4_meningitis
/
4_pneumonia
Asunto principal:
Infecciones Neumocócicas
/
Haemophilus influenzae
/
Vacunas Conjugadas
/
Vacunas contra Haemophilus
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Vacuna Neumocócica Conjugada Heptavalente
/
Infecciones por Haemophilus
/
Hospitales Universitarios
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Child
/
Child, preschool
/
Humans
/
Infant
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Nippon Med Sch
Asunto de la revista:
MEDICINA
Año:
2018
Tipo del documento:
Article