Differential responsiveness of central noradrenergic and dopaminergic neuron tyrosine hydroxylase to hypophysectomy, ACTH and glucocorticoid administration.
Ann N Y Acad Sci
; 297: 284-94, 1977 Oct 28.
Article
en En
| MEDLINE
| ID: mdl-29550
ABSTRACT
Hypophysectomy leads to a small increase in tyrosine hydroxylase activity of all brain areas containing noradrenergic neurons or tuberoinfundibular dopamine neurons, but nigroneostriatal dopamine neurons are not so affected. ACTH or corticosterone treatment inhibited this effect of hypophysectomy in some noradrenergic neurons and in tuberoinfundibular dopamine neurons. These data showing differential responsiveness of tyrosine hydroxylase in different brain areas are compatible with differences in regulation or molecular form of tyrosine hydroxylase in central noradrenergic and dopaminergic neurons. The disparity between increased hypothalamic tyrosine hydroxylase activity and decreased norepinephrine turnover following hypophysectomy may result from a change in the rate-limiting step to the hydroxylation of dopamine.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Dopamina
/
Norepinefrina
/
Hormona Adrenocorticotrópica
Límite:
Animals
Idioma:
En
Revista:
Ann N Y Acad Sci
Año:
1977
Tipo del documento:
Article