The active role of Ca2+ ions in Aß-mediated membrane damage.
Chem Commun (Camb)
; 54(29): 3629-3631, 2018 Apr 05.
Article
en En
| MEDLINE
| ID: mdl-29577161
ABSTRACT
Calcium dysregulation, membrane leakage and Aß amyloid growth are hallmarks of Alzheimer's disease. Here we show that Ca2+ ions inhibit membrane damage due to amyloid channels but enhance membrane disruption associated with fibers growing on the lipid surface. The similarities with IAPP suggest that this may represent a mechanism common to all proteinopathies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Membrana Celular
/
Calcio
/
Péptidos beta-Amiloides
Límite:
Animals
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Italia
