Resilience of small intestinal beneficial bacteria to the toxicity of soybean oil fatty acids.
Elife
; 72018 03 27.
Article
en En
| MEDLINE
| ID: mdl-29580380
ABSTRACT
Over the past century, soybean oil (SBO) consumption in the United States increased dramatically. The main SBO fatty acid, linoleic acid (182), inhibits in vitro the growth of lactobacilli, beneficial members of the small intestinal microbiota. Human-associated lactobacilli have declined in prevalence in Western microbiomes, but how dietary changes may have impacted their ecology is unclear. Here, we compared the in vitro and in vivo effects of 182 on Lactobacillus reuteri and L. johnsonii. Directed evolution in vitro in both species led to strong 182 resistance with mutations in genes for lipid biosynthesis, acid stress, and the cell membrane or wall. Small-intestinal Lactobacillus populations in mice were unaffected by chronic and acute 182 exposure, yet harbored both 182- sensitive and resistant strains. This work shows that extant small intestinal lactobacilli are protected from toxic dietary components via the gut environment as well as their own capacity to evolve resistance.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_zoonosis
Asunto principal:
Aceite de Soja
/
Ácido Linoleico
/
Limosilactobacillus reuteri
/
Microbioma Gastrointestinal
/
Lactobacillus johnsonii
/
Intestino Delgado
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Elife
Año:
2018
Tipo del documento:
Article
País de afiliación:
Alemania