Cryo-EM structure of <i>Escherichia coli</i> &#963;<sup>70</sup> RNA polymerase and promoter DNA complex revealed a role of &#963; non-conserved region during the open complex formation.

Narayanan, Anoop; Vago, Frank S; Li, Kunpeng; Qayyum, M Zuhaib; Yernool, Dinesh; Jiang, Wen; Murakami, Katsuhiko S

Cryo-EM structure of Escherichia coli σ⁷⁰ RNA polymerase and promoter DNA complex revealed a role of σ non-conserved region during the open complex formation.

Narayanan, Anoop; Vago, Frank S; Li, Kunpeng; Qayyum, M Zuhaib; Yernool, Dinesh; Jiang, Wen; Murakami, Katsuhiko S.

Afiliación

Narayanan A; Department of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802; Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, Indiana 47906.
Vago FS; Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, Indiana 47906.
Li K; Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, Indiana 47906.
Qayyum MZ; Department of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802.
Yernool D; Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, Indiana 47906.
Jiang W; Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, Indiana 47906. Electronic address: jiang12@purdue.edu.
Murakami KS; Department of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802. Electronic address: kum14@psu.edu.

J Biol Chem ; 293(19): 7367-7375, 2018 05 11.

Article en En | MEDLINE | ID: mdl-29581236

Asunto(s)

Microscopía por Crioelectrón/métodos; ADN Bacteriano/genética; Proteínas de Unión al ADN/metabolismo; ARN Polimerasas Dirigidas por ADN/química; Proteínas de Escherichia coli/química; Escherichia coli/enzimología; Regiones Promotoras Genéticas; Factor sigma/química; ADN Bacteriano/química; ARN Polimerasas Dirigidas por ADN/metabolismo; Escherichia coli/genética; Proteínas de Escherichia coli/metabolismo; Genes Bacterianos; Genes Esenciales; Conformación de Ácido Nucleico; Unión Proteica; Conformación Proteica; Factor sigma/metabolismo; Sitio de Iniciación de la Transcripción; Transcripción Genética

Palabras clave

RNA polymerase; cryo-EM; cryo-electron microscopy; open complex; promoter; promoter DNA; structural biology; transcription; σ non-conserved region

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_neglected_diseases / 3_zoonosis Asunto principal: Factor sigma / ARN Polimerasas Dirigidas por ADN / ADN Bacteriano / Regiones Promotoras Genéticas / Microscopía por Crioelectrón / Proteínas de Escherichia coli / Proteínas de Unión al ADN / Escherichia coli Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article

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