PD-1 and PD-L1 Up-regulation Promotes T-cell Apoptosis in Gastric Adenocarcinoma.
Anticancer Res
; 38(4): 2069-2078, 2018 04.
Article
en En
| MEDLINE
| ID: mdl-29599324
ABSTRACT
BACKGROUND/AIM:
The programmed death 1 (PD-1) receptor and its ligand (PD-L1) play pivotal roles in regulating host immune responses. However, the inhibitory effects of this pathway on the function of tumor infiltrating T lymphocytes in gastric adenocarcinoma patients are not well-defined. MATERIALS ANDMETHODS:
We characterized the expression of PD-1 and PD-L1 in peripheral blood and tumor infiltrating cells and analyzed the association between PD-1/PD-L1 expression and disease progression in a cohort of 60 patients with Helicobacter pylori infection, including 18 with gastric adenocarcinoma, 23 with gastritis, and 19 asymptomatic controls.RESULTS:
Relative to controls, the expression of PD-1 on peripheral blood and tumor infiltrating T cells increased with disease progression. In vitro, T cells induced PD-L1 expression on primary gastric adenocarcinoma epithelial cells in an IFN-γ-dependent manner, which in turn promoted T cells apoptosis. Blocking of PD-L1 reversed this effect.CONCLUSION:
This study provides evidence for a new therapeutic target in gastric adenocarcinoma patients.Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_digestive_diseases
/
6_stomach_cancer
Asunto principal:
Neoplasias Gástricas
/
Linfocitos T
/
Adenocarcinoma
/
Linfocitos Infiltrantes de Tumor
/
Apoptosis
/
Antígeno B7-H1
/
Receptor de Muerte Celular Programada 1
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Anticancer Res
Año:
2018
Tipo del documento:
Article